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Prostate cancer · Expert video

Can Lu-PSMA Therapy Defer ADT?

A focused discussion of early Lu-PSMA therapy, androgen deprivation therapy and the evidence questions that matter in hormone-sensitive or oligometastatic prostate cancer.

Presented byDr. Ishita B. SenDepartment of Nuclear Medicine, FMRI · Recorded 2024
Expert explainer · English/Hindi as recordedA complete transcript is available below.

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Lu PSMA has been approved by the US FDA for Metastatic Catsration Resistant Prostate Cancer, but many patients ask me, can we not use Lutetium PSMA therapy early on? Can we not use it in Hormone sencstive prostate Cancer.

There are many studies and in our own experience as well patients can opt for Lutetium Therapy in hormone sensitive Prostate Cancer or Oligo-metastatic prostate Ca or small volume metatstatic disease. It does help in deferrring ADT (Androgen Deprivation Therapy), there are many patient for whom the side effects of Androgen Deprivation Therapy (ADT) are unacceptable. These may include:

  1. Loss of Muscle
  2. Loss of Hair
  3. Loss of Libido
  4. Gynecomastia - where the breasts of male patients enlarge

These are known side effects of Androgen Deprivation Therapy (ADT) which may not be acceptable to many men.

And in this kind of cases and specially in patient with small volume metatstic disease, patients can have Metastatis Directed Lutetium PSMA therapy even in Hormone Sensitive or Early On Prostate Cancer treatment.

Caution: There is no hard and large data available to support this but Anecdotal data is available which supports the fact that Lu PSMA therapy does help in defrerring Andorgen Deprivation Therapy (ADT)

Read Also: Prostate Cancer Treatment


Note:
The content provided on this video is for informational purposes only and is not intended as a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.

Medical information notice: This video is educational and does not replace an individual consultation. Treatment suitability depends on current imaging, pathology, prior therapy, organ function and multidisciplinary clinical review.

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Medical disclaimer All physicians and researchers profiled on this page hold appointments at the Department of Nuclear Medicine & Molecular Imaging, Fortis Memorial Research Institute, Gurugram. Theranostic Physicians Private Limited (TPPL) is the clinical practice entity through which they consult and treat patients. Treatment outcomes vary by individual case; clinical decisions are made on the basis of complete medical records, current imaging, and a multidisciplinary review.