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So what happens is that you do an angiography just same way as a transarterial radioembolization or a transarterial chemoembolization is done, and you inject the PRRT medicine directly into the liver.
And the tumour cells in the liver, because they are very vascular, because they receive their blood supply from branches of the hepatic artery, they absorb the PRRT medicine in the first pass. So the first time that the medicine actually reaches the target tumour cells, it is absorbed and extracted from the bloodstream by these cells.
As a result, we are able to actually deliver a much higher dose of this medicine directly into the liver. So this is called intra-arterial PRRT, and recent studies have shown that it improves the effectiveness of PRRT without increasing the toxicity to a large extent.
Medical information notice: This recording is educational and reflects the discussion at the time of publication. It does not replace an individual consultation. Treatment suitability depends on current evidence, imaging, pathology, prior treatment, organ function and specialist review.